ZOLOFT (Brand for SERTRALINE HCL)

Sertraline Hydrochloride 50mg, Oral tablet

Grapefruit juice

· Severity: Mild

· Notes for Consumers: It is not clear if a significant interaction occurs between grapefruit juice and sertraline. Do not significantly change your daily intake of grapefruit and grapefruit juice. Also, the Sertraline Oral Solution should not be mixed in grapefruit juice; this solution is only mixable with water, ginger-ale, lemonade, orange juice or lemon-lime soda; do not mix in any other liquids.

· Notes for Professionals: Advise patients to not significantly alter their intake of grapefruit juice while taking sertraline until more data are available. Grapefruit juice has been reported to inhibit the metabolism of sertraline, elevating sertraline trough concentrations. It is not clear if the interaction is clinically significant for patients. The theorized mechanism is the inhibition of sertraline metabolism via CYP3A4; however, sertraline is known to be metabolized by many CYP enzymes, and inhibition of one enzyme is not likely to significantly affect sertraline pharmacokinetics.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>