ZILRETTA

Triamcinolone Acetonide 32mg, Powder for suspension for injection, Extended Release

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Limit your intake of grapefruit and grapefruit juice during triamcinolone treatment. Ingesting large or regular quantities of grapefruit juice or grapefruit may increase the risk for side effects from Triamcinolone. Tell your health care provider if you have side effects like roundness of the face, high blood pressure, weight gain, increased hunger or thirst, extreme irritability or hallucinations, fainting, stomach pain, or water retention as soon as possible. Topical skin products containing triamcinolone are not expected to interact.

· Notes for Professionals: Grapefruit or grapefruit juice may inhibit the CYP3A4 metabolism of triamcinolone, resulting in increased plasma triamcinolone concentrations and reduced serum cortisol concentrations. It is possible that a patient could experience increased corticosteroid effects including, but not limited to, Cushing syndrome and adrenal suppression. Advise patients to limit or avoid grapefruit juice during triamcinolone therapy. Monitor for excessive cortcosteroid effects, like Cushing's syndrome or adrenal suppression.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>