Yondelis Food, Alcohol, Supplements and Drug Interactions

YONDELIS

QTY 1 • 1 MG • VIAL • Near 77381

TRABECTEDIN (tra BEK te din) treats sarcoma, a cancer that occurs in bone and connective tissues, such as fat, muscle, and blood vessels. It works by slowing down the growth of cancer cells.

YONDELIS Lifestyle Interactions

Trabectedin 1mg, Powder for solution for injection

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Grapefruit Juice with Trabectedin. Side effects from Trabectedin may get worse if you take Grapefruit Juice. Discuss any new or worsening side effects with your health care provider.

· Notes for Professionals: Avoid the concomitant use of trabectedin with grapefruit juice due to the risk of increased trabectedin exposure. Trabectedin is a CYP3A substrate and grapefruit juice is a strong CYP3A inhibitor. Coadministration with another strong CYP3A inhibitor increased the systemic exposure of a single dose of trabectedin (0.58 mg/m2 IV) by 66% compared to a single dose of trabectedin (1.3 mg/m2) given alone.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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DISCOUNT ONLY - NOT INSURANCE. Discounts are available exclusively through participating pharmacies. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. This program does not make payments directly to pharmacies. Members are required to pay for all prescription purchases. Cannot be used in conjunction with insurance. You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. This program is administered by Medical Security Card Company, LLC, Tucson, AZ.

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