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RIVAROXABAN (ri va ROX a ban) prevents or treats blood clots. It is also used to lower the risk of stroke in people with AFib (atrial fibrillation). It can be used to lower the risk of heart attack or stroke in people with heart or peripheral artery disease. It belongs to a group of medications called blood thinners.
Rivaroxaban 20mg, Oral tablet
Grapefruit juice
· Severity: Major
· Notes for Consumers: Tell your health care professional that you drink Grapefruit Juice before you take Rivaroxaban. If you drink Grapefruit Juice and take Rivaroxaban, your risk of bleeding is increased. Immediately report any unusual bleeding or bruising.
· Notes for Professionals: Avoid concomitant administration of rivaroxaban and grapefruit juice; significant increases in rivaroxaban exposure may increase bleeding risk. Rivaroxaban is a substrate of CYP3A4/5 and the P-glycoprotein (P-gp) transporter. Grapefruit juice is a combined P-gp inhibitor and strong CYP3A4 inhibitor. Concurrent use of a single dose of rivaroxaban and ritonavir, a combined P-gp and strong CYP3A4 inhibitor, led to an increase in the steady-state rivaroxaban AUC by 150% and to an increase in Cmax by 60%. Similar increases in pharmacodynamic effects such as factor Xa inhibition and PT prolongation were also observed.
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Number of Uses:
xarelto
20 MG | Tablet | 30 tablets
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