TRAZODONE HCL

Trazodone Hydrochloride 150mg, Oral tablet

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.

Trazodone Hydrochloride 150mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of falling. Call emergency services right away if you experience symptoms of CNS depression: slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake.

· Notes for Professionals: Advise patients to avoid alcohol consumption while taking CNS depressants. Alcohol consumption may result in additive CNS depression.

Trazodone Hydrochloride 150mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Trazodone and Grapefruit Juice or grapefruit-containing foods together without talking to your health care provider. Side effects from Trazodone may be increased which can increase the risk of a dangerous change in heartbeat or heart rhythm.

· Notes for Professionals: Advise patients to avoid coadministration of trazodone with grapefruit juice due to the potential for increased trazodone exposure and associated adverse effects including QT prolongation. Trazodone is a CYP3A4 substrate; grapefruit juice is a strong CYP3A4 inhibitor. Coadministration of other strong CYP3A4 inhibitors increased the exposure of trazodone compared to the use of trazodone alone.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>