TOPOTECAN HCL (Generic for HYCAMTIN)

Topotecan Hydrochloride 4mg, Powder for solution for injection

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Topotecan with Grapefruit Juice without talking with your health care provider. Side effects of Topotecan may get worse. Tell your health care provider immediately if you notice any new or unusual side effects including fever, chills, cough, sore throat, pain or difficulty passing urine, blood in the urine, bruising, pinpoint red spots on the skin, black, tarry stools, unusually weak or tired, feeling faint or lightheaded, falls, or diarrhea.

· Notes for Professionals: Avoid taking oral topotecan with grapefruit juice due to increased topotecan exposure; grapefruit juice may be taken with intravenous topotecan. Oral topotecan is a substrate of P-glycoprotein (P-gp) and grapefruit juice is a P-gp inhibitor. Oral administration within 4 hours of another P-gp inhibitor increased the dose-normalized AUC of topotecan lactone and total topotecan 2-fold to 3-fold compared to oral topotecan alone.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>