TIGLUTIK

Riluzole 5mg/1mL, Oral suspension

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis.

· Notes for Professionals: Advise patients to avoid cannabis use during riluzole treatment due to decreased exposure of riluzole which may alter its efficacy. Cannabis use induces CYP1A2 and riluzole is a CYP1A2 substrate. The induction potential of cannabis is greatest with chronic inhalation. Other routes of administration or sporadic use may have less of an effect.

Riluzole 5mg/1mL, Oral suspension

Tobacco

· Severity: Major

· Notes for Consumers: Do not smoke or use tobacco products while taking this medication. When used together, your medication may not work as well for you.

· Notes for Professionals: Advise patients to avoid smoking tobacco while taking riluzole. Smoking tobacco has been observed to enhance riluzole clearance by greater than 20% which may decrease riluzole exposure and result in loss of efficacy. Riluzole is a CYP1A2 substrate and smoking tobacco induces CYP1A2.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>