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SERTRALINE/Zoloft (SER tra leen) treats depression, anxiety, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). It increases the amount of serotonin in the brain, a hormone that helps regulate mood. It belongs to a group of medications called SSRIs.
Sertraline Hydrochloride 100mg, Oral tablet
Grapefruit juice
· Severity: Mild
· Notes for Consumers: It is not clear if a significant interaction occurs between grapefruit juice and sertraline. Do not significantly change your daily intake of grapefruit and grapefruit juice. Also, the Sertraline Oral Solution should not be mixed in grapefruit juice; this solution is only mixable with water, ginger-ale, lemonade, orange juice or lemon-lime soda; do not mix in any other liquids.
· Notes for Professionals: Advise patients to not significantly alter their intake of grapefruit juice while taking sertraline until more data are available. Grapefruit juice has been reported to inhibit the metabolism of sertraline, elevating sertraline trough concentrations. It is not clear if the interaction is clinically significant for patients. The theorized mechanism is the inhibition of sertraline metabolism via CYP3A4; however, sertraline is known to be metabolized by many CYP enzymes, and inhibition of one enzyme is not likely to significantly affect sertraline pharmacokinetics.
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Number of Uses:
sertraline hcl
100 MG | Tablet | 90 tablets
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