SEREVENT DISKUS

Salmeterol 50mcg/1actuation, Inhalation powder

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Caffeine-sensitive persons may experience nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, or other side effects. Some patients may need to limit or avoid excessive caffeine intake from foods, beverages, dietary supplements or medicines. Caffeine containing items include coffee, teas, colas, chocolate and some dietary supplements or non-prescription medicines.

· Notes for Professionals: Caffeine may enhance the cardiac inotropic effects of beta-agonists.

Salmeterol 50mcg/1actuation, Inhalation powder

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not drink grapefruit juice or eat grapefruit or grapefruit-containing foods while taking salmeterol. Side effects from salmeterol may get worse. Contact your care team immediately if you experience any new or unusual side effects.

· Notes for Professionals: Advise patients to avoid grapefruit and grapefruit juice during salmeterol treatment due to the risk of increased salmeterol exposure and adverse reactions. Salmeterol is a CYP3A substrate and grapefruit juice is a strong CYP3A inhibitor.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>