SAVAYSA

Edoxaban 60mg, Oral tablet

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Although an interaction is possible, these drugs may be used together. Taking these drugs together may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding. Signs of bleeding may include increased bruising, pinpoint red spots on your skin, nosebleeds, bleeding gums, blood in the urine, or black, tarry stools.

· Notes for Professionals: Coadministration of edoxaban and grapefruit juice may result in increased concentrations of edoxaban. Edoxaban is a P-glycoprotein (P-gp) substrate and grapefruit juice is a P-gp inhibitor. Increased concentrations of edoxaban may occur during concomitant use of grapefuit juice; monitor for increased adverse effects of edoxaban. Dosage reduction may be considered for patients being treated for deep venous thrombosis (DVT) or pulmonary embolism.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>