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RILUZOLE/Rilutek (RIL yoo zole) treats amyotrophic lateral sclerosis (ALS). It works by protecting nerve cells, which delays worsening symptoms.
Riluzole 50mg, Oral tablet
Cannabis
· Severity: Major
· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis.
· Notes for Professionals: Advise patients to avoid cannabis use during riluzole treatment due to decreased exposure of riluzole which may alter its efficacy. Cannabis use induces CYP1A2 and riluzole is a CYP1A2 substrate. The induction potential of cannabis is greatest with chronic inhalation. Other routes of administration or sporadic use may have less of an effect.
Riluzole 50mg, Oral tablet
Tobacco
· Severity: Major
· Notes for Consumers: Do not smoke or use tobacco products while taking this medication. When used together, your medication may not work as well for you.
· Notes for Professionals: Advise patients to avoid smoking tobacco while taking riluzole. Smoking tobacco has been observed to enhance riluzole clearance by greater than 20% which may decrease riluzole exposure and result in loss of efficacy. Riluzole is a CYP1A2 substrate and smoking tobacco induces CYP1A2.
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Number of Uses:
riluzole
50 MG | Tablet | 180 tablets
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