QUINIDINE GLUCONATE

Quinidine Gluconate 324mg, Oral tablet, extended release

Grapefruit juice

· Severity: Major

· Notes for Consumers: Side effects from Quinidine may get worse if you take Grapefruit juice. Do not take Quinidine and Grapefruit juice together. Grapefruit juice can raise the level of Quinidine in the blood, which could increase the chance of side effects from Quinidine such as nausea/vomiting, a slow heart rate, or dizziness. Contact your prescriber immediately if you experience fainting or falling spells, palpitations, shortness of breath, or a change in your usual heart beat (fast, slow, or irregular heart beat) while taking Quinidine. Discuss with your health care provider why you should avoid grapefruit juice intake when taking Quinidine.

· Notes for Professionals: Grapefruit juice contains an unknown compound that inhibits cytochrome P-450 3A4 isozymes in the gut wall. Coadministration of quinidine with grapefruit juice to healthy volunteers delayed quinidine absorption and inhibited the conversion of quinidine to the major metabolite. Although the clinical significance of the interaction is unknown, concomitant administration with grapefruit juice should be avoided.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>