PROPAFENONE HCL

Propafenone Hydrochloride 150mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Side effects from Propafenone may get worse if you take Grapefruit juice. Do not take Propfenone and Grapefruit juice together. Grapefruit juice can raise the level of Propafenone in the blood, which could increase the chance of side effects from Propafenone such as nausea/vomiting, a slow heart rate, or dizziness. Contact your prescriber immediately if you experience fainting or falling spells, palpitations, shortness of breath, or a change in your usual heart beat (fast, slow, or irregular heart beat) while taking Propafenone. Discuss with your health care provider why you should avoid grapefruit juice intake when taking Propafenone.

· Notes for Professionals: Drugs that inhibit CYP1A2 and CYP3A4 can be expected to increase the serum concentrations of propafenone. When propafenone is co-administered with inhibitors of CYP1A2 or CYP3A4, the patients should be closely monitored and the dosage of propafenone adjusted as needed to meet therapeutic goals. Grapefruit juice is a CYP 3A4 inhibitor.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>