NICARDIPINE HCL (Generic for CARDENE I.V.)

Nicardipine Hydrochloride 30mg, Oral capsule

Grapefruit juice

· Severity: Major

· Notes for Consumers: Avoid taking Nicardipine with grapefruit juice. Grapefruit juice and grapefruit-containing foods may increase the effects of Nicardipine. If the blood pressure drops too low while taking this medicine, you may become dizzy or feel faint; do not stand or sit up too quickly. Contact your prescriber if you have dizziness which does not go away while taking this medicine. If you notice new or increased swelling of your legs or ankles, tell your health care provider.

· Notes for Professionals: Grapefruit juice contains compounds that inhibit the cytochrome P-450 CYP3A4 isozyme in the gut wall. Grapefruit juice can increase the serum concentrations and oral bioavailability of nicardipine. Co-administration of oral nicardipine with grapefruit juice significantly increases the AUC and peak plasma concentrations of nicardipine; the half-life of nicardipine is not affected. Grapefruit juice does not affect the pharmacokinetics of IV nicardipine. It is generally recommended to avoid grapefruit juice ingestion during nicardipine therapy.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>