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DRONEDARONE (droe NE da rone) treats a fast or irregular heartbeat (arrhythmia). It works by slowing down overactive electric signals in the heart, which stabilizes your heart rhythm. It belongs to a group of medications called antiarrhythmics.
Dronedarone 400mg, Oral tablet
Grapefruit juice
· Severity: Moderate
· Notes for Consumers: Consuming grapefruit juice can increase the side effects of Dronedarone. Contact your prescriber immediately if you experience unexplained muscle aches, muscle pain or tenderness, general weakness or fatigue, side or back pain, or decreased urination while taking Dronedarone.
· Notes for Professionals: Concomitant use of dronedarone and grapefruit juice should be avoided. Dronedarone is metabolized by CYP3A. Grapefruit juice is a moderate inhibitor of CYP3A4. The concomitant administration of dronedarone and grapefruit juice results in an increase in dronedarone exposure by 3-fold and increase in dronedarone Cmax of 2.5-fold. No data exist regarding the appropriate dose adjustment needed to allow safe administration of dronedarone and grapefruit juice.
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Number of Uses:
multaq
400 MG | Tablet | 60 tablets
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