MIFEPRISTONE (Generic for KORLYM)

Mifepristone 200mg, Oral tablet

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of cannabis may be altered if used with your medication. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use during mifepristone treatment. Concomitant use may alter the exposure of some cannabinoids and increase the risk for adverse reactions. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A and CYP2C9 substrates and mifepristone is a strong CYP3A and moderate CYP2C9 inhibitor. Concomitant use of a cannabinoid product containing THC and CBD at an approximate 1:1 ratio with another strong CYP3A inhibitor increased THC, 11-OH-THC, and CBD peak exposures by 1.3-, 3-, and 1.9-fold respectively.

Mifepristone 200mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Grapefruit juice or grapefruit-containing foods and Mifepristone together without talking to your health care provider. Side effects may get worse if you take these together. Contact your health care provider immediately if you experience nausea, vomiting, decreased appetite, headache, unusual tiredness or weakness, muscle weakness or cramps, palpitations or a change in your heartbeat (such as a fast or irregular heartbeat), or any other new or worsening side effects.

· Notes for Professionals: Advise patients to avoid grapefruit juice while taking mifepristone due to increased mifepristone exposure. Mifepristone is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>