MARPLAN

Isocarboxazid 10mg, Oral tablet

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.

Isocarboxazid 10mg, Oral tablet

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Do not drink alcohol for 14 days after stopping this medication. Drinking alcohol while taking this medication, or within 14 days after stopping this medication, may alter the effects of your medication. Serious side effects may occur. Contact your care team if you experience new or worsening side effects.

· Notes for Professionals: Alcohol may cause additive CNS depression and some alcohol-containing products may also contain tyramine. Many manufacturers contraindicate the use of alcohol during traditional, non-selective MAOI therapy such as treatment with isocarboxazid, phenelzine, or tranylcypromine. Certain alcohol-containing beverages thatare tyramine-rich can precipitate a hypertensive reaction if consumed by patients during therapy with these MAOIs. These include some beers; wines; sherry; hard liquor; or liqueurs.

Isocarboxazid 10mg, Oral tablet

Caffeine-containing Foods/Beverages

· Severity: Major

· Notes for Consumers: Do not take these drugs together without talking to your health care provider. Rapid heartbeats or serious increases in blood pressure, known as "hypertensive crisis", may occur. Try to avoid or limit all preparations containing caffeine such as tea, coffee, chocolate, cola. Do not take nonprescription medicines that contain Caffeine, like "stay awake" or weight loss products, including herbal diet aids. Caffeine restrictions should continue for at least 2 weeks after stopping an MAOI.

· Notes for Professionals: Excessive use of caffeine in any form should be avoided in patients receiving Monoamine oxidase inhibitors (MAOIs). Limit caffeine intake during MAOI use and for 1 to 2 weeks after discontinuation of any MAOI. The use of non-prescription medicines or dietary supplements containing caffeine should be avoided. Patients should try to avoid or limit the intake of all items containing caffeine such as tea, coffee, chocolate, and cola. Cardiac arrhythmias or severe hypertension may occur because of the potentiation of caffeine's sympathomimetic effects by MAOIs if caffeine intake is excessive.

Isocarboxazid 10mg, Oral tablet

Tyramine-containing foods

· Severity: Severe

· Notes for Consumers: Follow all instructions of your health care provider for your diet while taking this medicine. Avoid foods and beverages containing tyramine while taking this medicine. Tyramine-rich foods and drinks can cause serious increases in blood pressure. The following foods can cause sudden blood pressure increases and should be avoided: aged cheese; yeast extract; protein extract; soy sauce; fava bean or broad bean pods; smoked meats; pickled meats; smoked poultry; pickled poultry; smoked fish (lox, smoked salmon); pickled fish (pickled herring); fermented sausage (bologna, pepperoni, salami, summer sausage); bananas; avocados; any over-ripe fruit. Dietary and beverage restrictions for these drugs should continue for at least 2 weeks after stopping this medicine. Ask your health care professional for a full list of foods and beverages to avoid.

· Notes for Professionals: Avoid foods and beverages containing a high tyramine content. Ingestion of high tyramine foods can cause a hypertensive reaction. Following discontinuation of any MAOI, dietary restrictions should continue for at least 2 weeks due to the slow recovery from the enzyme-inhibiting effects of these drugs. According to product labeling, a variety of tyramine-containing foods can precipitate severe hypertensive episodes if consumed with MAOIs: aged cheese; yeast extract; protein extract; soy sauce; fava bean or broad bean pods; smoked meats; pickled meats; smoked poultry; pickled poultry; smoked fish (lox, smoked salmon); pickled fish (pickled herring); fermented sausage (bologna, pepperoni, salami, summer sausage) or other fermented meat; liver; anchovies; sauerkraut; bananas; overripe avocados; canned figs; raisins; raspberries; any over-ripe fruit; yogurt; and sour cream. Modifications to established guidelines are available through independent sources, supported by updated analytical methods for determining tyramine content of foods, and using a safety threshold of less than 6 mg of tyramine/serving. Certain foods that are prohibited in product labeling have been found to contain little or no tyramine. Milk products including sour cream, yogurt, and processed cheese slices do not contain tyramine. The tyramine content of brewer's yeast, baker's yeast, raspberries, and avocados is low. In some analyses, avocados have been shown to contain 0 to 2.3 mg of tyramine/100 g serving. Other allowable foods according to independent sources include cottage cheese, cream cheese, freshly packaged meat or fish, beef/chicken bouillon, bananas, chocolate, peanuts, properly stored pickled or smoked fish, and soy milk. Improper storage and handling of foods, or spoilage may increase tyramine content and present a risk of hypertensive crisis. Some alcohol-containing products may also contain tyramine. Beverages that contain tyramine can precipitate a hypertensive reaction if consumed during therapy with an MAOI. These include some beers (including reduced-ethanol and ethanol-free beer); wines (red and white varieties); sherry; hard liquor; or liqueurs.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>