LOSARTAN POTASSIUM (Generic for COZAAR)

Losartan Potassium 50mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not drink grapefruit juice or eat grapefruit while taking this medication. Grapefruit may alter the effects of your medication.

· Notes for Professionals: Advise patients to avoid grapefruit and grapefruit juice during losartan treatment due to the risk for decreased exposure to the active metabolite of losartan and decreased losartan efficacy. Losartan is converted to a more active metabolite via CYP2C9 and grapefruit juice is a CYP2C9 inhibitor. Coadministration with a moderate CYP2C9 inhibitor in two pharmacokinetic studies with healthy volunteers decreased concentrations of the active metabolite of losartan by 30% to 56%.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>