JULUCA

Dolutegravir 50mg, Rilpivirine 25mg, Oral tablet

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Side effects from Rilpivirine may get worse if you take Grapefruit juice. Grapefruit juice may decrease the elimination of Rilpivirine from the body, and increase the amount of Rilpivirine in the bloodstream. Your prescriber may decide that taking these drugs together is beneficial for you based on your health conditions. Discuss your drug regimen and health conditions with your health care provider.

· Notes for Professionals: Close clinical monitoring is advised when administering grapefruit juice with rilpivirine due to an increased potential for rilpivirine-related adverse events. Although this interaction has not been studied, predictions can be made based on metabolic pathways. Grapefruit juice is an inhibitor of the hepatic isoenzyme CYP3A4; rilpivirine is metabolized by this isoenzyme. Coadministration may result in increased rilpivirine plasma concentrations.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>