IRINOTECAN HCL (Generic for CAMPTOSAR)

Irinotecan Hydrochloride 20mg/1mL, Solution for injection

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Irinotecan with Grapefruit Juice. If you notice new or worsening side effects such as fever or chills, sore throat, bruising, pinpoint red spots on the skin, unusual weakness or tiredness, diarrhea, difficulty breathing, nausea, vomiting, stomach pain and/or cramping, contact your health care provider immediately. Discuss any new or worsening side effects with your health care provider.

· Notes for Professionals: Advise patients to avoid regular consumption of grapefruit or grapefruit juice during treatment with irinotecan and for at least 1 week prior to starting therapy. Irinotecan is a CYP3A4 substrate and grapefruit juice is a strong CYP3A4 inhibitor. Concomitant use may increase systemic exposure of irinotecan and its active metabolite, SN-38.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>