Iclusig Food, Alcohol, Supplements and Drug Interactions

ICLUSIG

QTY 30 • 45 MG • Tablet • Near 77381

PONATINIB (poe NA ti nib) treats leukemia. It works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

ICLUSIG Lifestyle Interactions

Ponatinib 45mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Avoid Grapefruit or Grapefruit Juice while taking Ponatinib. Side effects from Ponatinib may get worse. Notify your health care provider if you experience fluid retention, bleeding, rash, high blood pressure, or any other new or unusual side effects.

· Notes for Professionals: Instruct patients to avoid grapefruit or grapefruit juice with ponatinib due to the potential for increased ponatinib exposure and subsequent toxicity. Ponatinib is a CYP3A4 substrate; grapefruit juice is a strong CYP3A4 inhibitor. Coadministration with another strong CYP3A4 inhibitor increased the ponatinib AUC by 78%.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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Prescription prices may vary from pharmacy to pharmacy and are subject to change. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy.

DISCOUNT ONLY - NOT INSURANCE. Discounts are available exclusively through participating pharmacies. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. This program does not make payments directly to pharmacies. Members are required to pay for all prescription purchases. Cannot be used in conjunction with insurance. You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. This program is administered by Medical Security Card Company, LLC, Tucson, AZ.

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