HYALURONIC-NIACINAM-TACROLIMUS (Generic for ELYZIA)

Niacinamide 4%, Topical cream

Alcohol

· Severity: Moderate

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication may cause facial flushing or redness.

· Notes for Professionals: Alcohol-containing beverages or hot beverages/foods can exacerbate cutaneous vasodilation caused by niacin and should be avoided around the time of niacin ingestion.

Niacinamide 4%, Topical cream

Food

· Severity: Moderate

· Notes for Consumers: Avoid drinking hot beverages or eating hot food around the times you take Niacin. Ingesting hot food or beverages may worsen skin flushing (example: warm and reddened skin of the face, neck, or chest) while taking Niacin. Alcoholic beverages may also have this effect, so also avoid drinking alcohol around the time of your Niacin dose. Taking Niacin with meals may help to decrease skin flushing.

· Notes for Professionals: Hot beverages and foods can exacerbate cutaneous vasodilation caused by niacin and should be avoided around the time of niacin ingestion. In general, this interaction would not be harmful, but might decrease patient tolerance of niacin.

Tacrolimus 0.1%, Topical cream

Grapefruit juice

· Severity: Severe

· Notes for Consumers: Avoid grapefruit juice while taking Tacrolimus. Grapefruit and Grapefruit juice increase Tacrolimus blood levels significantly leading to side effects like stomach pain, confusion, trouble passing urine or change in the amount of urine, dizziness, headache, mood changes, nausea, vomiting, tremor, yellowing o eyes or skin, or feeling unusually weak or tired. An interaction with topical Tacrolimus is unlikely.

· Notes for Professionals: Grapefruit and grapefruit juice consumption by patients receiving tacrolimus should be avoided; concurrent use may increase tacrolimus serum concentrations and increase the risk of toxicity. Tacrolimus is a sensitive CYP3A4 substrate with a narrow therapeutic index; grapefruit juice is a strong CYP3A4 inhibitor.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>