HIXDEFRIMA

Fluconazole 1%, Topical solution

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Although an interaction is possible, these drugs are often used together. Side effects from Caffeine may get worse if you take Fluconazole. Too much Caffeine can cause effects like nausea, nervousness, or sleeplessness. You may need to limit your Caffeine intake. Common foods and beverages containing caffeine include coffee, teas, colas and chocolate. Many non-prescription drugs and diet aids may also contain caffeine.

· Notes for Professionals: Fluconazole has been shown to inhibit the clearance of caffeine by 25 percent. The clinical significance of these interactions has not been determined.

Fluconazole 1%, Topical solution

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of cannabis may be altered if used with your medication. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use during fluconazole treatment. Concomitant use may alter the exposure of some cannabinoids and increase the risk for adverse reactions. The cannabinoid delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are CYP3A and CYP2C9 substrates and fluconazole is a moderate CYP3A and CYP2C9 inhibitor.

Terbinafine Hydrochloride 1%, Topical solution

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Although an interaction is possible, these drugs may be used together with caution. Taking these drugs together may increase the risk for side effects. If your doctor decides that taking these drugs together is right for your condition, you will be closely monitored. Immediately report any new or worsening side effects to your health care provider.

· Notes for Professionals: Due to the risk for terbinafine related adverse effects, caution is advised when coadministering grapefruit juice. Although this interaction has not been studied by the manufacturer, and published literature suggests the potential for interactions to be low, administration may increase the systemic exposure of terbinafine. Terbinafine is metabolized by at least 7 CYP isoenyzmes, with major contributions coming from CYP2C9 and CYP3A4; grapefruit juice is an inhibitor of these enzymes. Monitor patients for adverse reactions.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>