Gavreto Food, Alcohol, Supplements and Drug Interactions

GAVRETO

QTY 60 • 100 MG • Capsule • Near 77381

PRALSETINIB (pral SE ti nib) treats lung cancer and thyroid cancer. It works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

GAVRETO Lifestyle Interactions

Pralsetinib 100mg, Oral capsule

Grapefruit juice

· Severity: Major

· Notes for Consumers: Avoid grapefruit and grapefruit juice during therapy with Pralsetinib. Side effects may get worse if you drink Grapefruit juice while taking Pralsetinib. Discuss any new or worsening side effects, such as diarrhea, nausea, abdominal pain, and fatigue, with your health care provider.

· Notes for Professionals: Have patients avoid grapefruit or grapefruit juice during pralsetinib treatment due to an increased risk of neratinib-related toxicity. Pralsetinib is a CYP3A and P-glycoprotein (P-gp) substrate and grapefruit juice is a combined P-gp and strong CYP3A inhibitor. Coadministration with another combined P-gp and strong CYP3A inhibitor increased the AUC of pralsetinib by 251%.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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