Eplerenone Food, Alcohol, Supplements and Drug Interactions

EPLERENONE (Generic for INSPRA)

QTY 90 • 25 MG • Tablet • Near 77381

EPLERENONE/Inspra (e PLER en one) treats high blood pressure and heart failure. It may also be used to prevent further damage after a heart attack. It helps your kidneys remove more fluid and salt from your blood through the urine without losing too much potassium. It belongs to a group of medications called diuretics.

EPLERENONE (Generic for INSPRA) Lifestyle Interactions

Eplerenone 25mg, Oral tablet

Grapefruit juice

· Severity: Severe

· Notes for Consumers: Do not take these drugs together. Discuss possible alternative treatment options with your prescriber. Taking these drugs together can increase the amount of Eplerenone in your blood and may cause your blood pressure to be too low or increase the amount of potassium in your blood. When there is too much potassium in the blood it can cause muscle weakness or an abnormal heart rhythm.

· Notes for Professionals: Concomitant use of grapefruit or grapefruit juice and eplerenone is contraindicated. Grapefruit potently inhibits the hepatic CYP3A4 isoenzyme and may increase serum eplerenone concentrations by about 25% and, hence, can increase the risk of developing eplerenone-induced hyperkalemia and hypotension.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>

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Prescription prices may vary from pharmacy to pharmacy and are subject to change. The pricing estimates given are based on the most recent information available and may change based on when you actually fill your prescription at the pharmacy.

DISCOUNT ONLY - NOT INSURANCE. Discounts are available exclusively through participating pharmacies. The range of the discounts will vary depending on the type of prescription and the pharmacy chosen. This program does not make payments directly to pharmacies. Members are required to pay for all prescription purchases. Cannot be used in conjunction with insurance. You may contact customer care anytime with questions or concerns, to cancel your registration, or to obtain further information. This program is administered by Medical Security Card Company, LLC, Tucson, AZ.

*Average and up to savings percentages are based on all discounted prescriptions that were run through the WellRx program in 2022. Discount percentages represent savings provided off of pharmacies’ retail prices for consumers who do not have a discount program and pay cash.

The day supply is based upon the average dispensing patterns for the specific drug and strength. The Program, as well as the prices and the list of covered drugs, can be modified at any time without notice.

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