DULERA

Mometasone 100mcg/1actuation, Formoterol 5mcg/1actuation, Pressurized inhalation, suspension

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Caffeine-sensitive persons may experience nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, or other side effects. Some patients may need to limit or avoid excessive caffeine intake from foods, beverages, dietary supplements or medicines. Caffeine containing items include coffee, teas, colas, chocolate and some dietary supplements or non-prescription medicines.

· Notes for Professionals: Caffeine may enhance the cardiac inotropic effects of beta-agonists.

Mometasone 100mcg/1actuation, Formoterol 5mcg/1actuation, Pressurized inhalation, suspension

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: These agents may be taken together with close supervision from your prescriber. Taking these drugs together could result in serious side effects such as mood changes; nausea, vomiting; dizziness; feeling faint or lightheaded, falls; unusually weak or tired; high blood pressure; skin changes; weight loss or gain. Report any of these effects immediately should they occur.

· Notes for Professionals: Consumption of grapefruit or grapefruit juice while taking mometasone may increase systemic exposure to mometasone, increasing the risk of corticosteroid-related adverse events. Avoid consistent consumption of grapefruit and its juice while on mometasone therapy; those who do consume grapefruit regularly should be monitored closely for hypercorticism and adrenal suppression. Mometasone is a CYP3A4 substrate and grapefruit is a strong CYP3A4 inhibitor.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>