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SUFENTANIL (soo FEN ta nil) treats severe pain. It is prescribed when other pain medications have not worked or cannot be tolerated. It works by blocking pain signals in the brain. It belongs to a group of medications called opioids.
Sufentanil 30mcg, Sublingual tablet
Cannabis
· Severity: Major
· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.
· Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.
Sufentanil 30mcg, Sublingual tablet
Alcohol
· Severity: Major
· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of an opioid overdose. Call emergency services right away if you experience symptoms of CNS depression: slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake. Talk to your care team about naloxone, a medication for the emergency treatment of opioid overdose.
· Notes for Professionals: Advise patients to avoid alcohol consumption while taking opioids. Alcohol consumption may result in additive CNS depression and may increase the risk for opioid overdose. Consider the patient's use of alcohol when prescribing opioid medications. If the patient is unlikely to be compliant with avoiding alcohol, consider prescribing naloxone especially if additional risk factors for opioid overdose are present.
Sufentanil 30mcg, Sublingual tablet
Grapefruit juice
· Severity: Moderate
· Notes for Consumers: Although an interaction is possible, Sufentanil is only used in a hospital or clinic. You may feel drowsy or more tired when taking this combination together. Do not drive or operate machinery until you know how the combination affects you. Discuss any new or worsening side effects, such as breathing problems, confusion, constipation, dizziness, trouble passing urine or change in the amount of urine, dry mouth and eyes, changes in vision, or fast heartbeat with your health care provider.
· Notes for Professionals: Because the dose of the sufentanil sublingual tablets cannot be titrated, consider an alternate opiate if grapefruit juice is regulary consumed. Consider a reduced dose of sufentanil injection with frequent monitoring for respiratory depression and sedation if patient consumes grapefruit juice. If grapefruit juice intake is significantly reduced or stopped, consider increasing the sufentanil injection dose until stable drug effects are achieved and monitor for evidence of opioid withdrawal. Sufentanil is a CYP3A4 substrate, and coadministration with a strong CYP3A4 inhibitor like grapefruit juice can increase sufentanil exposure resulting in increased or prolonged opioid effects including fatal respiratory depression, particularly when an inhibitor is added to a stable dose of sufentanil. If grapefruit juice intake is significantly reduced or stopped, sufentanil plasma concentrations will decrease resulting in reduced efficacy of the opioid and potential withdrawal syndrome in a patient who has developed physical dependence to sufentanil.
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Number of Uses:
dsuvia
30 MCG | TAB IN APP | 1 unit
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