DOXORUBICIN HCL LIPOSOME (Generic for DOXIL)

Doxorubicin, Liposomal 2mg/1mL, Solution for injection

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Doxorubicin and Grapefruit Juice together without talking to your health care provider. Discuss possible alternative treatment options with your health care provider. Side effects from Doxorubicin can get worse, including an increased risk of infection or immunosuppression. If you get a fever, sore throat or other possible signs of an infection while receiving treatment, do not treat yourself. Discuss any new or worsening side effects with your health care provider.

· Notes for Professionals: Grapefruit juice is a potent CYP3A4 inhibitor, a moderate inhibitor of P-glycoprotein (P-gp), and an in vitro inhibitor of CYP2D6; doxorubicin is a major substrate of CYP2D6, CYP3A4, and P-gp. Clinically significant interactions have been reported when doxorubicin was coadministered with inhibitors of CYP2D6, CYP3A4, and/or P-gp, resulting in increased concentration and clinical effect of doxorubicin. Avoid coadministration of grapefruit juice and doxorubicin if possible. If not possible, closely monitor for increased side effects of doxorubicin including myelosuppression and cardiotoxicity.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>