BUSPIRONE HCL

Buspirone Hydrochloride 10mg, Oral tablet

Food

· Severity: Major

· Notes for Consumers: Buspirone may be taken with or without food. However, grapefruit juice and grapefruit-containing foods may increase the risk of side effects of Buspirone, like drowsiness. Do not significantly alter grapefruit juice intake while taking this drug, or avoid grapefruit juice if possible.

· Notes for Professionals: Buspirone should be taken consistently with or without food because food decreases the presystemic clearance of buspirone.

Buspirone Hydrochloride 10mg, Oral tablet

Grapefruit juice

· Severity: Major

· Notes for Consumers: Avoid drinking large amounts of grapefruit juice intake while taking buspirone. Grapefruit juice may increase the levels of buspirone in the body and increase the risk of side effects like drowsiness, dizziness, nausea, headache, nervousness, or restlessness.

· Notes for Professionals: Patients receiving buspirone should be advised to avoid drinking large amounts of grapefruit juice. In a study in healthy volunteers, coadministration of buspirone (10 mg single dose) with grapefruit juice (200 mL double-strength three times daily for 2 days) increased plasma buspirone concentrations significantly (4.3-fold increase in Cmax; 9.2-fold increase in AUC). Subjective drowsiness and other side effects of buspirone, like dizziness, nausea, headache, nervousness, or restlessness. may be increased with grapefruit juice ingestion.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>