BUPRENORPHINE (Generic for BUTRANS)

Buprenorphine 10mcg/1h, Transdermal patch - Weekly

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Grapefruit juice and grapefruit-containing foods may increase the side effects of Buprenorphine. Do not significantly alter grapefruit juice intake while taking this drug, or avoid grapefruit juice if possible. If you notice slurred speech, confusion, severe weakness, difficulty breathing, palpitations, shortness of breath, or a change in your usual heart beat (fast, slow, or irregular heart beat), contact your health care prescriber.

· Notes for Professionals: Since the metabolism of buprenorphine is mediated by CYP3A4, consumption of grapefruit juice, a strong CYP3A4 inhibitor, may decrease the clearance of buprenorphine resulting in prolonged or increased opioid effects. Dose adjustments of buprenorphine may be necessary in patients who regularly consume grapefruit juice. The effect of CYP3A4 inhibitors on buprenorphine implants has not been studied, and the effect may be dependent on the route of administration.

Buprenorphine 10mcg/1h, Transdermal patch - Weekly

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis. Call emergency services right away if you experience slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, or trouble staying awake.

· Notes for Professionals: Advise patients to avoid cannabis use while taking CNS depressants due to the risk for additive CNS depression and potential for other cognitive adverse reactions.

Buprenorphine 10mcg/1h, Transdermal patch - Weekly

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of falling. Call emergency services right away if you experience symptoms of CNS depression: slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake.

· Notes for Professionals: Advise patients to avoid alcohol consumption while taking CNS depressants. Alcohol consumption may result in additive CNS depression.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>