BENZOYL-CLINDA-NIAC-TRETINOIN (Generic for ADERMICA)

Clindamycin 1%, Topical gel

Grapefruit juice

· Severity: Moderate

· Notes for Consumers: Although an interaction is possible, Clindamycin and Grapefruit Juice may be used together with caution. Side effects may get worse if you take these drugs together. Discuss any new or worsening side effects, such as diarrhea, abdominal pain, and vomiting, with your health care provider.

· Notes for Professionals: Monitor for an increase in clindamycin-related adverse reactions with coadministration of grapefruit juice as concurrent use may increase clindamycin exposure. Clindamycin is a CYP3A4 substrate; grapefruit juice is a strong inhibitor of CYP3A4.

Niacinamide 2%, Topical gel

Alcohol

· Severity: Moderate

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication may cause facial flushing or redness.

· Notes for Professionals: Alcohol-containing beverages or hot beverages/foods can exacerbate cutaneous vasodilation caused by niacin and should be avoided around the time of niacin ingestion.

Niacinamide 2%, Topical gel

Food

· Severity: Moderate

· Notes for Consumers: Avoid drinking hot beverages or eating hot food around the times you take Niacin. Ingesting hot food or beverages may worsen skin flushing (example: warm and reddened skin of the face, neck, or chest) while taking Niacin. Alcoholic beverages may also have this effect, so also avoid drinking alcohol around the time of your Niacin dose. Taking Niacin with meals may help to decrease skin flushing.

· Notes for Professionals: Hot beverages and foods can exacerbate cutaneous vasodilation caused by niacin and should be avoided around the time of niacin ingestion. In general, this interaction would not be harmful, but might decrease patient tolerance of niacin.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>