BENDAMUSTINE HCL (Generic for TREANDA)

Bendamustine Hydrochloride 25mg, Powder for solution for injection

Cannabis

· Severity: Major

· Notes for Consumers: Discuss cannabis use with your care team. The effects of your medication may be altered if used with cannabis.

· Notes for Professionals: Advise patients to avoid cannabis use during bendamustine treatment due to decreased exposure of bendamustine which may alter its efficacy. Cannabis use induces CYP1A2 and bendamustine is a CYP1A2 substrate. The induction potential of cannabis is greatest with chronic inhalation. Other routes of administration or sporadic use may have less of an effect.

Bendamustine Hydrochloride 25mg, Powder for solution for injection

Tobacco

· Severity: Major

· Notes for Consumers: Do not smoke or use tobacco products while taking this medication. When used together, your medication may not work as well for you.

· Notes for Professionals: Advise patients to avoid tobacco products while receiving bendamustine. Smoking tobacco may cause a decrease in bendamustine exposure, which may result in decreased efficacy. Bendamustine is a CYP1A2 substrate and tobacco is a CYP1A2 inducer.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>