ASPIRIN-DIPYRIDAMOLE ER (Generic for AGGRENOX)

Aspirin 25mg, Dipyridamole 200mg, Oral capsule, extended release

Alcohol

· Severity: Major

· Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication increases the risk of stomach bleeding. Contact your care team right away if you experience bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds.

· Notes for Professionals: Concomitant ingestion of alcohol with salicylates, especially aspirin, ASA, increases the risk of developing gastric irritation and GI mucosal bleeding. Alcohol and salicylates are mucosal irritants and aspirin decreases platelet aggregation. Routine ingestion of alcohol and aspirin can cause significant GI bleeding, which may or may not be overt. Even occasional concomitant use of salicylates and alcohol should be avoided. Chronic ingestion of alcohol is often associated with hypoprothrombinemia and this condition increases the risk of salicylate-induced bleeding. Patients should be warned regarding the potential for increased risk of GI bleeding if alcohol-containing beverages are taken concurrently with salicylates.

Aspirin 25mg, Dipyridamole 200mg, Oral capsule, extended release

Caffeine-containing Foods/Beverages

· Severity: Major

· Notes for Consumers: Caffeine may decrease the actions of Dipyridamole when it is used during heart testing. Discuss your Caffeine intake (including intake of coffee, colas, teas, or herbal supplements) with your health care provider prior to any procedures or examinations involving heart function. However, when Dipyridamole is used on a regular basis to prevent blood clots and strokes, an interaction with Caffeine is not expected.

· Notes for Professionals: Methylxanthines, through antagonism of adenosine and thus pharmacologic-induced coronary vasodilation, have been associated with false-negative results during dipyridamole-thallium 201 stress testing. It is recommended that caffeine be discontinued for at least 24 hours prior to stress testing. An interaction is not expected when methylxanthines are used concomitantly with the chronic dipyridamole therapy.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>