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APREPITANT/Emend (ap RE pi tant) prevents nausea and vomiting from chemotherapy. It works by blocking substances in your body that may cause nausea and vomiting. It belongs to a class of medications called antiemetics.
Aprepitant 40mg, Oral capsule
Grapefruit juice
· Severity: Major
· Notes for Consumers: Do not take Aprepitant, Fosaprepitant with grapefruit juice. Increased side effects may be observed if these drugs are given together. Discuss possible alternative options with your health care provider.
· Notes for Professionals: Avoid the concomitant use of aprepitant, fosaprepitant with grapefruit juice due to substantially increased exposure of aprepitant. After administration, fosaprepitant is rapidly converted to aprepitant. Grapefruit juice is a strong CYP3A4 inhibitor and aprepitant is a CYP3A4 substrate. Coadministration of a single oral dose of aprepitant on day 5 of a 10-day ketoconazole regimen (strong CYP3A4 inhibitor) increased the aprepitant AUC approximately 5-fold, and increased the mean terminal half-life by approximately 3-fold.
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Number of Uses:
aprepitant
40 MG | Capsule | 1 capsule
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