24HR ALLERGY-CONGESTION RELIEF (Generic for ALLEGRA-D 24 HOUR)

Fexofenadine Hydrochloride 180mg, Pseudoephedrine Hydrochloride 240mg, Oral tablet, extended release 24 hour

Grapefruit juice

· Severity: Major

· Notes for Consumers: Do not take Fexofenadine with fruit juices, such as Grapefruit juice. Taking Fexofenadine at the same time as Grapefruit juice may reduce the effectiveness of this allergy medication in some people. Fexofenadine should be taken with water.

· Notes for Professionals: Fruit juices such as grapefruit juice, orange juice, and apple juice may reduce the bioavailability, systemic exposure, and clinical efficacy of fexofenadine. Patients should avoid drinking fruit juice within 4 hours before and 1 to 2 hours after taking fexofenadine; tablets and capsules should be consumed with water, not juice. Many fruit juices are organic anion transporting peptide (OATP) 1A2 and/or OATP2B1 inhibitors. OATP-mediated transport facilitates the intestinal absorption of fexofenadine. It is estimated that the bioavailability of fexofenadine is decreased by 36% when coadministered with grapefruit or orange juice. Apple juice, orange juice, and grapefruit juice have been reported to decrease the AUC and Cmax of fexofenadine by up to 70%.

Fexofenadine Hydrochloride 180mg, Pseudoephedrine Hydrochloride 240mg, Oral tablet, extended release 24 hour

Caffeine-containing Foods/Beverages

· Severity: Moderate

· Notes for Consumers: Limit caffeine intake (examples: coffee, teas, colas, chocolate and some herbal supplements) while taking Pseudoephedrine. Also avoid medicines containing additional Caffeine whenever possible. Side effects from Pseudoephedrine may get worse if you take excessive Caffeine. Taking a high amount of Caffeine can increase the risk of nausea, nervousness, palpitations, problems with sleep, rapid heartbeat, tremor, or other side effects.

· Notes for Professionals: Caffeine is a CNS-stimulant and such actions are expected to be additive when coadministered with other CNS stimulants or psychostimulants.

<b>DISCLAIMER:</b><em> This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Drug information is sourced from GSDD (Gold Standard Drug Database ) provided by Elsevier.</em>